Analytical Optimization of Multiunit Particulate System (MUPS) Tablet – A Novel Drug Delivery System

Abstract

Multiunit particulate delivery element of the drug is new emerging sake for the modified release and / or craving release solid dosage forms. In general, MUPS are consisted of thousands of tiny particles or pellets or micro-granules exhibiting same characteristics, which are formulated either in a form of tablet or directly filled in the capsule. In few cases it is delivered in the sachet as pellets as such. Active drug substance is present in these tiny particles. These delivery systems perceived advantageous over conventional solid dosage form drug delivery systems such as more uniform behaviour of absorption and less profound for the inter and intra subject variability. Tablets containing pellets are compelled to break rapidly and release the pellets in the dissolution media to release the required drug release profile. Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of drugs that persists analgesic (pain-killing) and antipyretic (fever-reducing) deliberate, and, in higher doses, anti-inflammatory effects.