One-pot multicomponent synthesis of 2-amino-5,6,7,8-tetrahydro-4-phenylquinoline-3-Carbonitrile Derivatives

Abstract

We report simple, efficient and one pot multicomponent protocol for the synthesis of the highly substituted 2-amino-5,6,7,8-tetrahydro-4-phenylquinoline-3-carbonitrile derivatives via the reaction of various aromatic aldehydes, malanonitrile, cyclic ketones and ammonium acetate in the presence of catalytic amount of cellulose based cerium (IV) as reusable catalyst at room temperature. For this transformation we used ethanol as green solvent and considering green chemistry approach. The synthesized compounds were characterized by FT- IR technique. The advantages of procedure include simplicity of operation, wide substrate scope, good yields, no chromatographic separation technique, and easy recovery & recyclability of the catalyst.