Effect of storage condition on the chemical stability of extemporaneous preparation of Omeprazole suspension.

Abstract

For the preparation of omeprazole suspension granules are available in the market. In this research suspension is prepared by using combination of vehicle, preservative and pH regulator. After preparation of chemical stability is evaluated by using stability indicating parameters. Chemical stability of suspension is significantly increased after pH maintain in strongly basic side.  Storage temperature plays significant role in chemical stability. Storage container has no significant impact on chemical stability. Due to use of polysorbet 80, shelf life is increased to significant extent due to its properties such as preservative agent, wetting agent, suspending agent. Research highlights novel suspension medium preparation, its impact on chemical stability. Temperature and storage container impact on stability.